Melinda G Hollingshead Selected Research

tepotinib

1/2018

Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors.

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Melinda G Hollingshead Research Topics

Disease

38	Neoplasms (Cancer) 01/2022 - 06/2002
6	Breast Neoplasms (Breast Cancer) 12/2023 - 09/2004
5	Neoplasm Metastasis (Metastasis) 01/2020 - 04/2007
5	Hypoxia (Hypoxemia) 07/2007 - 09/2002
4	Carcinoma (Carcinomatosis) 01/2021 - 09/2004
3	Leukemia 01/2021 - 09/2004
3	Glioma (Gliomas) 06/2006 - 09/2004
2	Carcinogenesis 01/2021 - 08/2013
2	Triple Negative Breast Neoplasms 01/2018 - 07/2012
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2022
1	Plexiform Neurofibroma 01/2021
1	Prostatic Neoplasms (Prostate Cancer) 01/2020
1	Sarcoma (Soft Tissue Sarcoma) 01/2020
1	Neurofibrosarcoma (MPNST) 01/2020
1	Colorectal Neoplasms (Colorectal Cancer) 01/2019
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018
1	Stomach Neoplasms (Stomach Cancer) 01/2018
1	Mitochondrial Diseases (Mitochondrial Disease) 10/2013
1	Starvation 10/2013
1	Osteosarcoma (Osteogenic Sarcoma) 01/2012

Drug/Important Bio-Agent (IBA)

7	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2012
6	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 09/2004
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 04/2008
4	Phosphotransferases (Kinase)IBA 01/2020 - 01/2013
4	4- (3- (2- nitro- 1- imidazolyl)- propylamino)- 7- chloroquinoline hydrochlorideIBA 07/2007 - 09/2002
4	Cytotoxins (Cytolysins)IBA 07/2007 - 09/2002
3	Paclitaxel (Taxol)FDA LinkGeneric 01/2020 - 12/2002
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2011 - 06/2003
2	Temozolomide (Temodar)FDA LinkGeneric 01/2022 - 10/2021
2	Transcription Factors (Transcription Factor)IBA 01/2018 - 07/2011
2	AntibodiesIBA 01/2018 - 06/2003
2	RNA (Ribonucleic Acid)IBA 10/2013 - 02/2009
2	AgarIBA 01/2013 - 07/2011
2	artemisinin (artemisinine)IBA 09/2009 - 01/2009
2	SuspensionsIBA 04/2008 - 04/2007
2	NSC 680410IBA 06/2007 - 03/2005
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 04/2007 - 09/2002
2	Cisplatin (Platino)FDA LinkGeneric 09/2004 - 07/2004
2	1,1'- ((propane- 1,3- diyl)dioxy)bis(7- methoxy- 2- methylidene- 1,2,3,10,11,11a- hexahydro- 5H- pyrrolo(2,1- c)(1,4)benzodiazepin- 5,11- dione)IBA 09/2004 - 09/2004
2	Tirapazamine (SR 4233)IBA 12/2002 - 09/2002
1	Decitabine FDA Link 12/2023
1	Azacitidine (5 Azacytidine)FDA Link 12/2023
1	palbociclibIBA 01/2022
1	alovudineIBA 01/2022
1	ThymidineIBA 01/2022
1	Anti-Obesity Agents (Antiobesity Drugs)IBA 01/2022
1	AZD 6244IBA 01/2021
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021
1	CytidineIBA 01/2021
1	MK 2206IBA 01/2021
1	AZD8186IBA 01/2021
1	Cadherins (E-Cadherin)IBA 01/2020
1	pazopanib FDA Link 01/2020
1	talazoparibIBA 01/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	CateninsIBA 01/2020
1	Tyrosine Kinase InhibitorsIBA 01/2020
1	silvestrolIBA 01/2020
1	Eukaryotic Initiation Factor-4F (EIF4F)IBA 01/2020
1	CaspasesIBA 01/2020
1	rocaglamideIBA 01/2020
1	nilotinib FDA Link 01/2020
1	VimentinIBA 01/2020
1	Insulin (Novolin)FDA Link 01/2020
1	TubulinIBA 01/2020
1	EMD1214063IBA 01/2018
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2018
1	cabozantinibIBA 01/2018
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2018
1	Indicators and Reagents (Reagents)IBA 01/2018
1	tepotinibIBA 01/2018
1	ARQ 197IBA 01/2018
1	GSK 1363089IBA 01/2018
1	defactinibIBA 01/2018
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2017
1	Membrane Proteins (Integral Membrane Proteins)IBA 02/2016
1	birinapantIBA 02/2016
1	5- ((2,6- dichlorobenzyl)sulfonyl)- 3- ((3,5- dimethyl- 4- ((2- (pyrrolidin- 1- ylmethyl)pyrrolidin- 1- yl)carbonyl)- 1H- pyrrol- 2- yl)methylene)- 1,3- dihydro- 2H- indol- 2- oneIBA 01/2016
1	CrizotinibIBA 01/2016
1	Complementary DNA (cDNA)IBA 05/2014
1	tyrosine receptor (receptor, tyrosine)IBA 05/2014
1	adavosertibIBA 05/2014
1	Oxyphenisatin Acetate (Oxyphenisatine)IBA 10/2013
1	Type I Tumor Necrosis Factor ReceptorsIBA 10/2013
1	estradiol 17 beta-cypionate (Depo-estradiol)FDA LinkGeneric 08/2013
1	AcidsIBA 08/2013
1	Coumaric AcidsIBA 08/2013
1	Fatty Acids (Saturated Fatty Acids)IBA 08/2013
1	decanoic acid (capric acid)IBA 08/2013
1	2,3-bis(3'-hydroxybenzyl)butyrolactone (enterolactone)IBA 08/2013
1	Sulfates (Sulfates, Inorganic)IBA 08/2013
1	GlucuronidesIBA 08/2013
1	SC1 compoundIBA 01/2013
1	GTP Phosphohydrolases (GTPases)IBA 01/2013
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 07/2012
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2012
1	Vincristine (Oncovin)FDA LinkGeneric 01/2012

Therapy/Procedure

10	Therapeutics 01/2022 - 06/2003
3	Drug Therapy (Chemotherapy) 12/2019 - 09/2002
2	Transplantation 04/2008 - 04/2007